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Salmonella test: relation between mutagenicity and number of revertant colonies.
N. van der Hoeven
1*
, S.A.L.M. Kooijman
2
and W.K. de Raat
1
Department of Biology, MT-TNO, 2600 AE Delft, The Netherlands
Biology Laboratory, Free University, 1007 MC Amsterdam, The Netherlands
*: Present address: ECOSTAT, Vondellaan 23, 2332 AA Leiden, The Netherlands
Abstract
This paper describes a model that relates the actual effect measured in the Salmonella test, i.e., the number of revertant colonies, to the mutation rate induced by a stable test compound having no side effects and acting without a time-lag. A maximum-likelihood estimator for the mutation rate is derived. Furthermore some side effects (mortality, increase in generation time, other mutations) are included in more extensive models. Side effects can cause a non-linear dose-response relation. Factors delaying the effect of the compound lead to an apparently higher mutation rate if a higher histidine dose is applied or a smaller inoculum is used. Factors slowly decreasing the effect of the compound reverse this result. Secondary effects of the test compound on the bacteria result in a non-linear dose-response relationship.
Mutation Research
234
: 289-302, 1990
Abstract sluiten
Een selectie uit de publikaties van
Nelly van der Hoeven
Is it safe to pool the Blank Control Data with the Solvent Control data? N. van der Hoeven,
Ecotoxicol. Environm. Safety
,
73
:1480-1483, 2010
Multi-criteria decision analysis of test endpoints for detecting the effects of endocrine active substances in fish full life cycle tests. M. Crane, M. Gross, P. Matthiessen, G.T. Ankley, S. Axford, P. Bjerregaard, R. Brown, P. Chapman, M. Dorgeloh, M. Galay-Burgos, J. Green, C. Hazlerigg, J. Janssen, K. Lorenzen, J. Parrott, H. Rufli, C. Schäfers, M. Seki, H.C. Stolzenberg, N. van der Hoeven, D. Vethaak, IJ. Winfield, S. Zok & J. Wheeler
Integr Environ Assess Manag.
,
6
: 378-389, 2010
Exposure analysis of bisphenol A in surface water systems in North America and Europe. (PMID:19746705) G.M. Klecka, C.A. Staples, K.E. Clark, N. van der Hoeven, D.E. Thomas & S.G. Hentges
Environmental Science & Technology
,
43
: 6145-6150, 2009
The Minimum Significant Difference at the NOEC calculated with a non-parametric test. Hoeven, N. van der, In: Proceedings of the 30th Anniversary Meeting of the Netherlands Society of Toxicology, june 2009. p. 122
Calculation of the Minimum Significant Difference at the NOEC using a non-parametric test. Hoeven, N. van der,
Ecotoxicol. Environm. Safety
,
70
: 61-66, 2008
Does bisphenol a induce superfeminization in Marisa cornuarietis? Part I: Intra- and inter-laboratory variability in test endpoints. Forbes, V.E., H. Selck, A. Palmqvist, J. Aufderheide, R. Warbritton, N. Pounds, R. Thompson, N. van der Hoeven & N. Caspers
Ecotoxicol. Environm. Safety
,
66
: 309-318, 2007
Does bisphenol A induce superfeminization in Marisa cornuarietis? Part II: Toxicity test results and requirements for statistical power analyses. Forbes, V.E., J. Aufderheide, R. Warbritton, N. van der Hoeven & N. Caspers
Ecotoxicol. Environm. Safety
,
66
: 319-325, 2007
Statistical issues in fish life-cycle tests with many endpoints. Hoeven, N. van der & D.R. Dietrich, Abstract and poster for SETAC Europe, May 2005, Lille
The probability to select the correct model using likelihood-ratio based criteria in choosing between two nested models of which the more extended one is true. Hoeven, N. van der,
Journal of Statistical Planning and Inference
,
135
: 477-486, 2005
Effects of bisphenol A on adult fathead minnow (P. promelas) gonadal histology: a 42-day exposure study. Dietrich, D.R., J. Wolf, A.R. Brown, J.E. Caunter, N. van der Hoeven & U. Friederich, Abstract and poster for the Cluster workshop on Ecological relevance of chemically induced endocrine disruption in wildlife. University of Exeter, july 2004.
The Netherlands working group on Statistics and Ecotoxicology: Statistics and Models for Risk Assessment. Hoeven, N. van der, In: Proceedings of the Jubilee Annual Meeting of the Netherlands Society of Toxicology, june 2004. p. 114
Current issues in statistics and models for Ecotoxicological Risk Assessment. Hoeven, N. van der,
Acta Biotheoretica
52
: 201-217, 2004
Balancing statistics and ecology: on the lumping of experimental data for model selection. Hoeven, N. van der, L. Hemerik & P.A. Jansen. In: T.A.C. Reydon & L. Hemerik (Eds): Current themes in Theoretical Biology: A Dutch Perspective. pp 233-265. Springer, Dordrecht, The Netherlands, 2004.
Using marine bioassays to classify the toxicity of Dutch harbour sediments. Stronkhorst, J., C. Schipper, J. Brils, M. Dubbeldam, J. Postma & N. van der Hoeven
Environmental Toxicology and Chemistry
,
22
: 1535-1547, 2003
What can egg distributions of solitary parasitoids tell us about the information the parasitoid has and uses for its oviposition decisions? Hemerik, L.,N. van der Hoeven & J. J.M. van Alphen,
Acta Biotheoretica
,
50
: 167-188, 2002
Statistical tests and power analysis for three in-vivo bioassays to determine the quality of marine sediments. Hoeven, N. van der, B. J. Kater & J. F. Pieters,
Environmetrics
13
: 281-293, 2002
Significance tables for the exact variance test for the Poisson distribution with alternative underdispersion. N. van der Hoeven & L Hemerik,
Environmental and Ecological Statistics
9
: 201-213, 2002
Estimating the 5-percentile of the species sensitivity distribution without any assumptions about the distribution. N. van der Hoeven,
Ecotoxicology
10
: 25-34, 2001
Power analysis for the NOEC: What is the probability to detect small toxic effects on three different species using the appropriate standardized test protocols? N. van der Hoeven,
Ecotoxicology
7
: 355-361, 1998
The acute toxicity of selected alkylphenols on young and adult
Daphnia magna
. A.A.M. Gerritsen, N. van der Hoeven & A. Pielaat,
Ecotoxicol. Environm. Safety
39
: 227-232. 1998
The ecotoxicity and the biodegradability of lactic acid, alkyl lactate esters and lactic acid salts. C.T. Bowmer, R.N. Hooftman, A.O. Hanstveit, P.W.M. Venderbosch & N. van der Hoeven,
Chemosphere
37
: 1317-1333, 1998
How to measure no effect? Part I: Towards a new measure of chronic toxicity in ecotoxicology. Introduction and workshop results. N. van der Hoeven, F. Noppert & A. Leopold,
Environmetrics
8
: 241-248, 1997
How to measure no effect? Part III: Statistical aspects of NOEC, EC
x
and NEC estimates. N. van der Hoeven,
Environmetrics
8
: 255-261, 1997
The effect of chlorpyrifos on individuals of
Daphnia pulex
in laboratory and field. N. van der Hoeven & A.A.M. Gerritsen,
Environm. Toxicol. Chem.
16
: 2438-2447, 1997
A model based on soil structural aspects describing the fate of genetically modified bacteria in soil. N. van der Hoeven & J.D. van Elsas,
Ecological Modelling
89
: 161-173, 1996
Competition between cohorts of juvenile
Daphnia magna
. E.L. Enserink, N. van der Hoeven, M. Smith, M. van der Klis & M.A. van der Gaag,
Archiv für Hydrobiologie
136
: 433-454, 1996
Reliability of quantitative toxicity test results: from experimental control to data processing. Enserink, E.L. & N. van der Hoeven,
The Science of the Total Environment, suppl. 1993
, Proceedings of the Second European Conference on Ecotoxicology, eds. W. Slooff & H. de Kruijf, p. 699-704, 1993
LC50 estimates and their confidence intervals. The case that only one test concentration has partial effect. N. van der Hoeven,
Water Research
25
: 401-408, 1991
Effects of toxicants on individuals and populations of Daphnia, a simulation study. N. van der Hoeven,
Comparative Biochemistry and Physiology
100C
: 283-286, 1991
Effect of 3,4-dichloroaniline and metavanadate on Daphnia populations. N. van der Hoeven,
Ecotoxicology and Environmental Safety
20
: 53-70, 1990
Salmonella test: Relation between mutagenicity and number of revertant colonies. N. van der Hoeven, S.A.L.M. Kooijman & W.K. de Raat,
Mutation Research
234
: 289-302, 1990
Superparasitism as an ESS: to reject or not to reject, that is the question. N. van der Hoeven & L. Hemerik,
J. of Theoretical Biology
146
: 467-482, 1990
Population consequences of a physiological model for individual development S.A.L.M. Kooijman, N. van der Hoeven & D.C. van der Werf,
Functional Ecology
3
: 325-336, 1989
Oscillations in
Daphnia
populations. N. van der Hoeven, A.M. de Roos & S.A.L.M. Kooijman,
Econieuws
2
, 7-8, 1989
The population dynamics of Daphnia at constant food supply: a review, re-evaluation and analysis of experimental series from the literature. N. van der Hoeven,
Netherlands Journal of Zoology
39
: 126-155, 1989
Random elements in a population model based on individual development. N. van der Hoeven, in: Ecodynamics, Proc. Int. Workshop at Jülich, FRG, 19-20 Oct. 1987. Eds. W. Wolff, C.J. Soeder & F.R. Drepper, pp 333-342, Research Notes in Physics, Springer Verlag., 1988
